Medication

SSRI Side Effects: What to Expect

Starting an SSRI? Learn common side effects, timelines, and when to contact your provider.

By Astrude Charles, PMHNP-BCApril 12, 20261 min read

Common early SSRI side effects include nausea, headache, sleep changes, and temporary anxiety increases.

Many side effects diminish within one to two weeks as your body adjusts.

Sexual side effects may persist and should be discussed openly with your PMHNP.

Never stop SSRIs abruptly — discontinuation symptoms can be uncomfortable and risky.

Follow-up visits monitor side effects and symptom improvement so adjustments can be made promptly.

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