Treatment-Resistant Depression: Options to Discuss
When antidepressants have not helped enough, other strategies may be worth exploring with your provider.
Treatment-resistant depression generally means inadequate response to at least two adequate antidepressant trials.
Options may include dose optimization, switching medications, augmentation strategies, or reviewing whether the diagnosis is complete.
Untreated ADHD, bipolar disorder, trauma, or substance use can mimic or worsen treatment resistance.
Therapy — especially evidence-based approaches — remains important alongside medication.
A thorough psychiatric evaluation reviews your full history before recommending next steps.
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